Greater Des Moines Top Employers and Key Industries

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Build your dream career with the right employer in Greater Des Moines (DSM). Whether you’re interested in working for a Fortune 500 company, joining a high-growth tech startup, being part of a flourishing creative scene, or anything in between, DSM offers opportunities to help move your career forward. With a wide range of employment options, you can find a place to grow your network and build the career you want. Browse job openings that are hiring now. These listings are sourced from employers across DSM and top job boards, giving you a full range of opportunities to explore. 

Major Employers in Greater Des Moines

Explore some of the best companies to work for in DSM and key industries, including advanced manufacturing, ag innovation, data centers, insurance and financial services, logistics and technology. Below is a brief overview of these industries and some of the companies you’ll find here. 

Because many of the largest companies in Iowa are headquartered in or have a strong presence in the region, there is no shortage of job opportunities in accounting, HR, marketing and management.

Advanced Manufacturing Industry

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Manufacturing continues to grow in the region as the global marketplace evolves and expands, with DSM companies making notable industry contributions, including: 

Ag Innovation Industry

Iowa is a national leader in the production of pork, eggs and corn and ranks #1 for the highest concentration of agricultural engineers and animal scientists. DSM is branded as America's Cultivation Corridor® due in part to the high concentration of agriculture and biotech companies located in the region, including: 

Data Centers Industry

Interested in working for a major tech company? DSM is home to several data centers. Find your dream job in DSM for a major tech player such as: 

  • Apple: A prominent hardware and software company 
  • Meta (Facebook): Social media and social networking  
  • Microsoft: Multinational tech corporation including cloud, computers, apps and gaming 
  • LightEdge Solutions: Compliant cloud hosting and colocation services 

Insurance and Financial Services Industry

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DSM is known nationally and internationally as an insurance hub, with a strong concentration of insurance and financial companies in the region. The area continues to rank among the top markets in the country for employment in these industries. Just to name a few major employers: 

Logistics Industry

DSM is in the heart of the Midwest and located at the crossroads of major Interstates I-80 and I-35. This central location makes DSM well-positioned for logistics, warehouse and distribution operations — including these major employers: 

  • Amazon: Distribution 
  • Casey's General Stores, Inc.: Gasoline, prepared food, fountain items, groceries and other merchandise 
  • UPS: Logistics and distribution, transportation and freight, customers brokerage 

Technology Industry

Named a Top 10 Best Midwest Tech Metro (CommercialCafe, 2026), technology innovation is thriving in DSM, with a growing tech sector and opportunities across a wide range of companies. Explore these employers to learn more: 

  • ESO: Software products for EMS agencies 
  • Landus Innovation Center: A farmer-owned cooperative that leverages data to connect key contributors across the ag supply chain
  • Lumen: Telecommunications, ISP 

Additional Major Employers in the Des Moines Region

Several other employers have a major presence in DSM and offer a wide variety of job opportunities. These employers include:

Small Businesses in DSM USA 

Interested in working for a small- or medium-sized business in DSM? Explore the Greater Des Moines Partnership’s directory of 7,200 Regional Chamber Member businesses found throughout the multi-county region.